Properly the Niceno-Constantinopolitan Creed, formulated at Nicea in AD 325 and expanded at the First Council of Constantinople in AD 381. This is the creed used universally in the historic liturgy of the Church — East and West — and is the most detailed Trinitarian confession of the ecumenical creeds. Its signature phrase concerning the Son is homoousion tō Patri — "of one substance with the Father" — which explicitly excludes Arianism.
The Nicene Creed is longer and more defensive than the Apostles' Creed because it was written to slam shut specific heresies. Of the Son: "eternally begotten... not made... of one substance with the Father... through whom all things were made." Every phrase aimed at Arius's claim that the Son was created. Of the Holy Spirit (added in 381): "the Lord, the giver of life, who proceeds from the Father [and the Son — the Latin filioque clause added in the West centuries later, which remains a point of contention with Eastern Orthodoxy], who with the Father and the Son is worshiped and glorified." The creed's other distinctives: baptism for the remission of sins, one holy catholic and apostolic Church (the four classical marks), resurrection of the dead, life of the world to come. To recite the Nicene Creed is to step into the confession of the Church across sixteen hundred years and virtually every continent. Rome, Constantinople, Wittenberg, Geneva, and Nairobi all say the same words.