Aischynē (G152) is the standard Greek word for shame — the sense of disgrace and dishonor, whether felt internally or imposed externally. In the NT it describes the shame of those caught in sin (Philippians 3:19; Jude 13), the shame that Christ endured on the cross (Hebrews 12:2), and the shame believers will be rescued from at Christ's return.
Hebrews 12:2 says Christ 'endured the cross, despising the aischynēn.' He took the full weight of human shame — public humiliation, nakedness, cursedness — and despised it. Not avoiding it, but treating it with contempt, because the joy set before him outweighed it. This is the ground of the believer's boldness: Jesus bore our shame so that we might stand unashamed before God.