A region in eastern Asia Minor (modern eastern Turkey). Though not directly mentioned in the NT by this exact form, it was part of the broader area where early Christianity spread in the first centuries.
The expansion of Christianity into Asia Minor, including regions like Melitene, fulfills the pattern of Acts 1:8 — the gospel spreading from Jerusalem to Judea, Samaria, and the ends of the earth. Paul's missionary journeys through Asia Minor laid the foundation for churches that would influence Christian history for centuries.