The Greek noun anoixis (ἄνοιξις) means opening or the act of opening, derived from anoigo (to open, G455). It appears once in the New Testament in Ephesians 6:19, where Paul requests prayer that "words may be given him... in opening his mouth boldly to make known the mystery of the gospel."
Paul's request for prayer for anoixis — the opening of his mouth — is profoundly humble. The man who wrote most of the New Testament epistles, who had visions and revelations, who stood before kings — this man asked for prayer to have the right words. The "opening of the mouth" language echoes the Psalms and prophets (Psalm 51:15; Ezekiel 3:27; 29:21). It acknowledges that true gospel proclamation is not the preacher's rhetorical skill but God's sovereign opening of the mouth. The same God who opened the mouths of prophets, who promised to give words to those brought before rulers (Matthew 10:19), is the one Paul trusted to open his for the sake of the mystery of Christ.