Hupostrepho appears 35 times in the New Testament, 21 of them in Luke-Acts. It simply means 'to return' or 'turn back' — but in Luke's narrative theology, returning is a significant spiritual motion. Jesus returns from the wilderness (Luke 4:14); the disciples return with joy after preaching (Luke 10:17); the leper who was healed returns to give thanks (Luke 17:15-18); the Prodigal Son 'comes to himself' and returns home.
Luke's use of hupostrepho is theologically rich. The one Samaritan leper who returned (Luke 17:15) to thank Jesus receives the declaration 'Your faith has made you whole' — the nine who did not return received physical healing but not wholeness. The Prodigal's return is the paradigm: 'he came to himself' and returned to his father's house. Jesus' disciples returned with joy — mission accomplished. Zechariah 1:3 ('Return to me and I will return to you') is the OT heartbeat behind every NT hupostrepho: God is always the destination to which His people are drawn back.