Achreioo (ἀχρειόω) means "to make useless, to corrupt, to render worthless." It appears once in Romans 3:12, where Paul quotes Psalm 14:3 (LXX) describing universal moral corruption: "All have turned away, they have together become worthless [ēchreōthēsan]."
Romans 3:12 is part of Paul's sweeping indictment of all humanity (Romans 3:9–20). The word achreioo — to be made worthless — describes sin's corrupting effect on human nature. This is not merely moral failure; it is the fundamental inability to function as God designed. The corruption is total in extent: all have turned away. This total corruption is the backdrop against which God's grace blazes: though humanity has been made worthless by sin, God in Christ makes us "a new creation" (2 Corinthians 5:17), restoring value and purpose.