Holos (ὅλος) means the whole, the totality, all of something — emphasizing completeness rather than mere quantity. It focuses on the unity of the whole rather than the count of the parts (unlike pas — every/all which stresses individual members). From holos comes the English prefix 'holo-' (holograph, holocaust [holo + kautos = whole burning], holistic).
The great commandment uses holos: 'Love the Lord your God with all (hole) your heart, and with all your soul, and with all your mind, and with all your strength' (Mark 12:30) — total, undivided, whole-person love with nothing held back. 1 Thessalonians 5:23: 'May the God of peace himself sanctify you wholly (holoteleis) — and may your whole (holokleron) spirit and soul and body be kept blameless.' The goal of sanctification is the wholeness of the entire person. Jesus's healing ministry often used holos: 'Your whole (hole) body is full of light' (Matthew 6:22). Sin fragments; grace makes whole.
The holos of the Shema and the Great Commandment reveals what God desires most: not partial devotion but whole-person, wholehearted commitment. The half-hearted believer is specifically condemned in Revelation 3:15-16: 'I wish that you were either cold or hot.' The lukewarm — the partial, the divided — is rejected. The power of holos is the call away from compartmentalization: God wants all of our heart, mind, soul, and strength — not the religious part but the whole human being integrated in love for the triune God.